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Nanomachines
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29 / M / US
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Posted 4/15/07
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33 / M / Cali
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Posted 4/15/07

jamehze wrote:

^ Ehh I'm not too sure about that. It's a nice idea, but still a wrong approach in my view. Those rods they mention are recognized for the folate proteins on the membrane of the cell. Simple mutations can cause resistance to that easily. It's a nice temporary idea, but it won't work as a definitive cure against cancer. It's another stepping stone, but it will lose its effectiveness over time at least.

Thanks for the article though.


well its because the cancer cells for some reason have an excess of folate, researchers are using it as a target marker for cancer. i dont think that it's something that cancer cells can develop a resistance to, since i think it is just a common byproduct produced by those cells. however it may or may not be a characteristic in all types of cancer cells. but scientists may design nanorods or nanoparticles to bind to other parts that are specific to that cancer cell.. not just folate.

wrt the question earlier about supressing oncogenes, actually in senior design project i mentioned earlier, i used nanoparticles to deliver gene suppressing RNAi to a localized site. so it's not going replace gene therapies, but complement them and increase their effectiveness. one of the obstacles for genetic treatments is to actually deliver it into the cell, and at the same time prevent it from being destroyed before it gets to the nucleus.

and before, people were using viral vectors.. basically taking a virus and altering it.. but that would be way more expensive, difficult to mass produce, and potentially have the risk of an active virus in there for wutever reason... and other methods have something like 20% effectiveness... with nanotechnology, because it's synthetic, you can potentially custom tailor the drug or therapy, whether it be little exploding bombs, medicine, or genetic treatments, by binding it your nanorod/nanoparticle/micelle/nanobox and setting them to go exactly where u want them to, and activating them exactly when you want... all while avoiding causing damage and complications to the healthy cells in the surrounding area.
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26 / M / Jersey
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Posted 4/15/07
The problem with surface proteins though are that they can constantly change. That's how plenty of bacteria grow resistance. The nanoparticles recognize any cancerous cells that have folate in the cell membrane and destroys those. There's bound to be a few cancerous cells that don't have the folate marker after all and survive to divide.

Cancer cells are known for their genomic instability and thus they tend to have various genomic aberrations that develop as time goes on, so I can only suspect that more there would be a lot of variability in their phenotypes.

Sounds like interesting stuff though. Thanks for teaching me.
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25 / F / at the computer duh
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Posted 4/15/07
i guess they're ok and they sound like they could help a lot so i like them
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29 / M / Aboard the Hyperion
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Posted 4/15/07
I guess for now we just keep on modifying recombinant DNA technology before a solid breakthrough using nanomachines can really supress cancer cells. Then again it can be quite bothersome if we have samples of bacteria that have fairly low transformation efficiency.
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26 / M / Body in NY Mind i...
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Posted 4/15/07
Well I can alrady see how all medical break throughs become defects. I assume that this might become worth looking into. We wont accomplish this technology until we focus on funding it for the breakthrough.(i`m gonna use and anime for relevance) If were lucky we might be able to stabalize our living conditions before this happens. But were not sophisticated enough for "ghost in the shell" cyber brain technical fantasy. But I know their working on that right now.
kira14 
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25 / M / Crying for a bett...
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Posted 4/15/07
It's all cool until the government gets their hands on it. They would probably use it for war and Gps tracking. By that time our children have children they might put nanochips into babies so they can know where people are who they are with and who knows what.
Posted 4/15/07
Ummm...overall no. They would do more harm than good. If even some were so go renegade they would all cause more trouble than it helped us.
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29 / M / Aboard the Hyperion
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Posted 4/15/07
We could look for another method other than nanomachines, like retroviral engineering. Let's take this different approach by building a logical technology tree. Lets begin with the basics and work our way up from there. You'll see many connections from today's technology and the possible technology of tomorrow.

Let's start with Biogenetics. Early inquiries into this field center on the prevention and treatment of health problems. Research in this discipline seek an understanding of the entire human genetic code. The Human Genome Project (HGP) and stem cell research revolves around biogenetics.

Biogenetics provide techniques for the incipent field of Gene Splicing. This technology allows researchers to insert new DNA coding into existing genetic material so that entire traits, from disease resistance to a stable personality, can be copied from one organism and transferred to any number of others.

All past research on memory, learning, the senses, and other aspects of the human brain did not answer one basic question: what is the biological mechanism of self-awareness? Research into biogenetics and social psych may resolve the last of the secrets of the human brain, providing mankind with understanding of the fundamentals of consciousness.

The insatiable drive for efficiency spawned by industrial automation drives the development of Neural Grafting. This new technology, based on secrets of the human brain, allows attachment of digital circuitry directly to the neural cortex. With these implants, humans willing to undergo neural grafting can enhance many aspects of their physical being, from heightened senses to faster reaction times.

Gene splicing and neural grafting exemplify crude and invasive techniques for modifying an organism. The more refined Bio-engineering method arranges a desired genetic code directly from the component compounds, enabling widespread and economical cellular transplants for an entire population.

Retroviral Engineering, a specialized branch of bio-engineering, uses engineered viruses to deliver genetic alterations. This application can be used for peaceful, healing purposes.
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37 / M / Tengukakushi
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Posted 4/15/07
I heard a few days ago that buckyballs...turns out they can damage human dna....recall....WHOOPS!!! I think thats the trouble with nanites. Dealing with machines on a molecular level in all types of industry....eventually they will come into contact with us and the environment and have unknown consequences. We just don't know enough yet. For good sci-fi on the topic read "the diamond age" by Stephenson.
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33 / M / Cali
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Posted 4/15/07
^^ haha i dunno.. if i were to be scared of any technology, it would be retroviral engineering.. thats like trying to tame a beast. if u screw up, ur giving the person ur trying to heal a virus... and if u were to mass produce these, it would be asking for someone to use it as a quick do-it-yourself biological weapon. these are self-replicating and can mutate so you can potentially cause an outbreak.. whereas synthesized nanomachines are dead materials... humans can control the production.. and they wont mutate on us.

if ur worried about machines going rogue on humans, it wont happen with nanomachines first.. artificial intelligence has to advance in regular-sized computers and machines before u can downscale it. and yeah, the damage and pollution to the environment is a real issue.. but its the same with chemicals.. of all things to worry about, nanomachines are not at the top of my list.. there are MUCH easier ways to destroy the world.
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23 / M / Underground
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Posted 4/15/07
lol...for me I guess it's useless!!
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26 / M / The Z-Lair Somewh...
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Posted 4/17/07
its something that we will face in the future as long as people keep trying to make it happen.
like all other things it will have its ups and downs and have kinks to work out.
like guns it will be used for good and bad things. i mean its started already in science fiction. look at all the ways nanomachines are viewed and treated and these stories and you get the idea.
its not the same. just like television it will have its detractors and supporters and most likely both sides will have there crazies.
i geuss thats all i really have to say.
Posted 4/17/07
Everyone knows from Uninhabitable Planet Survive that nanos give you psychic powers and a boosted healing factor. So who could ever be against them?
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32 / M
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Posted 11/24/07

kankokujin wrote:

I see no moral problems with it unlike embryonic stem cell research. I would say go ahead with it as long as they really know what they are doing. If you leave nanobots to do their own thing, they may decide to fix something that may not need fixing.


Agreed.
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