Tsuritama. Y'know, minus the aliens... I can relate to Yuki really well. Being really shy and socially awkward. Having a random, hyperactive person suddenly befriend you and drag you
everywhere. Learning to open up to people, make friends, move on from the past... Sounds like a lot of high school anime, haha, but Tsuritama's the only one that seemed
real to me. Plus the whole fishing theme helps me really connect to it. Makes me remember all the fishing trips I took with my dad when I was younger. I can remember the exact same sense of excitement and accomplishment that comes with catching your first fish, just like Yuki.

And Yuki's grandma being sick reminded me of when my dad was hospitalized. Sad times...
I seem to have written the most of anyone in this thread, pffft. Maybe I'm reading too much into the question xD