Takuto is a 16 year old who killed himself, by jumping off a cliff on his moterbike he was in a band with Mitsuki dad and Mitsuki doctor.(he also knew mitsuki mother)
He met Mistuki when she was very small at 1st he did't like her because he thought that she was the reason why the band spilt up, but he became to like her and find her very cute.
When Mitsuki was 12 he met her once again however he did not remember that he met her once before because saw her when she was 6 and when he was alive.
He is in a team with Meroko who saids she loves him but he knows she does not,she love izumi
who is on another team.
Takuto was supossed to die later but he killed himself and because he did that he became a shigami, to take children souls,
when he met Mitsuki he was surposed to take her soul in a year however he could't because he fell in love with her.
Takuto was the one who took Echi soul.

At the end of the manga Takuto goes away for 3 years but comes back there he sees mituki who is 16 now and they get together.

at the end of the anime takuto almost becomes a ghost but because Meroko said she will take his place but she does not become a ghost....... she becomes an angel instead Takuto becomes alive once again however he has forgotten everything meoko finds takuto and take him to a place where she get mitsuki to go as well Mitsuki shouts his name and takuto turns around and see her and said MItsuki

Meroko is a rabbit shinigami with long ears, capable of transforming into an anthropomorphic bunny stuffed toy. In the anime, she is fond of changing her appearance into other characters using the catchphrase "Mero Mero Change!" Meroko is Takuto's partner and is infatuated with him, though her love is unrequited. She is jealous of Takuto's affection for Mitsuki, and fears that being around Mitsuki will cause Takuto to remember his past, and thus become a ghost. Meroko was Izumi's former partner and was infatuated with him; when Izumi grew tired of her frequent declarations of love, he tricked her into training newcomer Takuto in his place. Although Meroko tries to fall in love with Takuto, she eventually realizes that she loved Izumi all along.
When Meroko was alive, she was Mitsuki's grandmother's best friend, Moe Rikyo (里匡萌, Rikyō Moe?) (of which her shinigami name is an anagram). Mitsuki's grandmother, Fuzuki, was engaged to be married when they both met, and fell in love with a violinist, Seijuro Koga. He loved Fuzuki, however, and eventually became engaged to her, whereupon her former fiancée was passed on to Moe. When Moe caught Fuzuki and the violinist kissing, she ran into the rain and committed suicide by slitting her wrists. Meroko is often linked to rain, and it is used as a symbol in the manga.

Izumi is a cold and distant shinigami assigned the Pediatrics Ward. He can transform into an anthropomorphic dog plushie, but rarely does so because it takes a lot of energy. He likes to call other characters by nicknames. In the manga, he first appears in Chapter 5; in the anime, he appears later, roughly halfway through the series.
In the manga, he is a tragic figure: in his human life, he was a six-year-old boy named Lio Izumi (泉利緒, Izumi Lio?) whose mother beat him because he looked like his dead father. To make his mother happy for once, he threw himself in front of a train, and while he saw his mother smile as he was hit, it did not satisfy him. Eventually, Mitsuki's gentleness makes Izumi realize that he had wanted his mother to call him back from the tracks. At the end of the manga, he and Meroko team up again as angels.
In the anime, Izumi's background is not mentioned and he is portrayed as a cold-hearted antagonist. He makes several attempts to steal Mitsuki's soul, and although he claims to love Meroko, he only seems to do things that cause her pain, as Takuto points out. He is responsible for Takuto and Meroko being assigned to Mitsuki, to get Takuto to remember his past life as a human by taking the soul of his former friend's daughter.

12-year-old girl who dreams of becoming a pop singer but a tumor in her vocal cords restricts her ability to sing. She is an orphan who grew up in an orphanage, then later went to live with her strict grandmother, Fuzuki, who forbid her from singing. When Mitsuki learned that she would die if her vocal cords were not removed, she refused the surgery, saying that she would rather die than not be able to sing. With Takuto's help, she can transform into Fullmoon a 16-year-old pop idol, completely free of cancer and able to sing. As Fullmoon, she is discovered by Seed Records during an audition and releases several singles in both the manga and anime; the anime ending theme songs are all supposedly sung by her. Mitsuki chooses the stage name Fullmoon both because mitsuki means "full moon" in Japanese and because her childhood friend, Eichi Sakurai, wants to become an astronomer and the name reminds her of him.
Mitsuki wants to become a singer because she wants to tell Eichi that she loves him. However, the shinigami eventually discover that Eichi is dead. In the manga, they realize that Mitsuki knew all along; in the anime, Mitsuki learns of his death during a trip to America. Both the manga and anime revolve around Mitsuki dealing with Eichi's death, as well as her eventual feelings for Takuto.

Mitsuki's childhood friend and first love. After his parents died, Eichi lived with his grandfather, then when he died as well, Eichi moved to the orphanage where he met Mitsuki. They became fast friends, and he eventually falls in love with her, confessing his feelings just before moving to America. Mitsuki was heartbroken when he left, as she could not yet confess her true feelings to him. Part of the reason she wants to become a singer is to find him. In the manga, Eichi dies when his flight to America crashes; in the anime, Eichi dies in a car accident a few months after moving.
In the manga, Takuto's first assignment was taking Eichi's soul, but Eichi refused to depart the world and instead stays near Mitsuki as a spirit, which gives her the power to see shinigami. He stays with her until the end of the manga, when he leaves after seeing that she is now happy and wants to live on, and no longer needs his presence.

Mitsuki's doctor. He played keyboard in the band ROUTE:L along with Mitsuki's father, Aoi Koga, and Takuto Kira, but he quit after Aoi's death. Fans called him the "Prince of ROUTE:L" because wakaōji means "young prince" in Japanese.
In the manga, Wakaoji performed the surgery on Takuto to remove the tumor in his vocal cords and witnessed Takuto's suicide. Mitsuki learns that Wakaoji loved her mother because of a letter he thought she had written him, but Wakaoji falls in love with Oshige when he discovers the letter was from her. In a side story, he asks Oshige to marry him and she accepts

Fullmoon's manager, and a former avid fangirl of ROUTE:L, especially Wakaoji. She started out as an unsuccessful idol singer, under the stage name Yuina Hanakazari, before moving to management. In the manga, she has an affair with her boss out of loneliness despite his being married, but she eventually starts dating Wakaoji. At the end of the manga, Oshige marries Wakaoji. In the anime, however, Wakaoji and Oshige have no romantic relationship and are merely friends.

Madoka Wakamatsu is the stage name of Chisato Kurebayashi. She is Fullmoon's rival in the music industry, who at the same time befriends 12-year-old Mitsuki. While talented, she is constantly upstaged by Fullmoon because she initially lacks the heart Mitsuki gives her songs. In addition, she is insecure because she had plastic surgery to make herself beautiful as a celebrity and was disowned by her family as a result. Madoka has a small pig called Gut-chan, who worships her; although she sometimes takes out her anger on him, she is genuinely fond of him.
In the manga, Madoka is shown as having pride as well as ambition: she refuses to cheat to win over Fullmoon, even once resigning a commercial offer to Fullmoon when she realizes that Fullmoon would have won if Madoka hadn't inadvertantly stolen her lyrics. In the anime, Madoka is not above using underhanded tactics to best Fullmoon and does so several times.