Animation-wise, the style of Gurren Lagann is pretty unique. Hiroyuki Imaishi was the Director on this and several similarly animated series: Dead Leaves, FLCL, and Kill La Kill. All also very good series, BTW.
The show is completely over-the-top. Larger than life, even. Just when you think they couldn't go any further or do any more, they do.
It's a show about coming of age. It's a ...