Appleseed (アップルシード, Appurushīdo?) is an anime film, directed by Shinji Aramaki and originally released in Japan on May 17, 2004. It is based on the characters created by Masamune Shirow in the original Appleseed manga series that was published in 1985. Although it shares some characters with the original series, this film's storyline is not connected to it. It is not to be confused with the 1988 OVA also based on the manga.

Source: Wikipedia