Sena, a timid, shy boy, finally passes the high-school entrance exam. Since he was a child, Sena had been bullied into running errands. He sees his entry into high school as a chance to re-invent himself positively, however the bullies soon have their eyes on him. Sena runs from his bullies with superb speed, having trained by running all those errands. The American football team captain Hiruma who heads his two-member club and who is notorious for his sadistic character, notices Sena's speed and threatens Sena to join the team. Incapable of saying no, timid Sena has no choice but to join the team and become the "Eye Shield 21…Lightning Speed".