This second season of Hana Yori Dango picks up right after Domyouji leaves for New York. After confessing to Domyouji, Makino has not spoken to him for a year. Rui and the other members of F4 try and help Makino meet Domyouji again by going to New York for the christmas holidays. Though F4 and Makino meet Domyouji again, he has become a completely different person, and so they leave for Japan.
Some time later, Domyouji's mother annouces that they will be returning to Japan. There, they hold a giant super-rich and classy birthday party for Domyouji and annouce something very important. Domyouji, like in the first season, is engaged to a rich girl and heir. The only difference is that they are to be wed soon. What will Makino do?
On the side, Rui begins to fall in love with Makino... will this become a love... square?
52nd Television Drama Academy Awards: Best Drama
2007 Annual Drama Grand Prix Awards: Best Supporting Actor - Oguri Shun
16th Hashida Awards: Rookie of the Year - Oguri Shun for 'Hana Yori Dango 2'
16th Hashida Awards: Rookie of the Year - Inoue Mao for 'Hana Yori Dango 2'
10th Nikkan Sports Drama Grand Prix (Jan-Mar 07): Best Drama
10th Nikkan Sports Drama Grand Prix (Jan-Mar 07): Best Actress - Inoue Mao
10th Nikkan Sports Drama Grand Prix (Jan-Mar 07): Best Supporting Actor - Matsumoto Jun