ICE (アイス?) is a 2007 original video animation created by Yasushi Akimoto and directed by Makoto Kobayashi. It is set in the ruins of Tokyo in the near future, after an unspecified catastrophe has led to the death of all human males and many females. The small groups of women who survive face the impending extinction of humanity. There are suggestions that the disaster was caused by human interference with nature, possibly biological warfare experiments or genetic engineering.
Many of the survivors blame men's warlike nature and scientific arrogance for the catastrophe. However, even though men have perished, the women who remain are forced to use violence in the face of bioterrorism and other threats. While some accept their fate as the last generation of humans, others see biological engineering as a final hope for the survival of the species.