Kamichama Karin is about a 7th grader named Karin Hanazono. Her parents and beloved cat, Shii-chan recently died, she`s getting horrible grades and is forced to live with her aunt. One day, Karin meets a young, orphaned, 7th grade boy named Kazune Kujyou, and discovers that her mother`s ring has the power to transform her into a goddess. She soon moves in with Kazune and his cousin Himeka. She and Kazune, who has godlike powers of his own, have to fight to protect Karin`s ring and Himeka from the evil intentions of Kirio Karasuma (whom Karin calls Mr. Glasses Man), who is also divine. The trio embark on crazy adventures and go on trips along the way. They also meet new friends and people, such as Micchi, who may know a lot of information not only about the divine transformation of the gods and goddesses, but also about Kazune-kun`s long lost father...
The Kamichama Karin manga series has been released into a total of seven full volumes. Koge-Donbo admits in volume one at how the point of Karin's "I am God" was to have her say something stupid and how the manga started was as a gag. Kamichama Karin was originally going to be a two chapter one-shot manga, according to Koge-Donbo. Due to its unexpected popularity, she continued the story. The story continues on in a sequel series Kamichama Karin Chu. again with seven volumes in regular special edition volumes released in Japan. The special edition volumes include the same basic content as the regular editions but include additional content making them highly valuable to manga collectors. The special editions feature different cover artwork including a gold foiled logo on a clear plastic dust jacket. Each special volume is accompanied by booklets which contain whole extra chapters to the story (usually the information in these extra chapters is supplementary, and not critical, to the main story).
An anime of Kamichama Karin debuted in Japan on April 6, 2007. Animation was done by the animation studio Satelight. The story starts off in Kamichama Karin Chu, the sequel to Kamichama Karin. Karin and Suzune are running through a park when Rika attacks Karin. Karin's Chronos Clock (which has the power to time-travel) gets the Seed of Chaos implanted into it and brings her to the first time she met Kazune at Shii-chan's grave. After that, the events follow the storyline of the manga. Kamichama Karin was shown in Japan every Saturday. An original soundtrack has been released.