Misty Tredwell, known as Misty Lola in the Japanese version, is a character from Yu-Gi-Oh! 5D's. She is a fashion model, who can read someone based on their facial appearance. She was a member of the Dark Signers with the Lizard dark mark, but was brought back to life following Goodwin's defeat.
Misty transforms into her Dark Signer regalia and begins the Shadow Duel, causing the Lizard geoglyph to form around the building. Akiza Summons "Black Rose Dragon", proving to Misty that she is a Signer. Shortly after saying she is avenging her brother, who was killed by Akiza, she Summons "Earthbound Immortal Ccarayhua", sacrificing hundreds of residents inside the geoglyph to do so. The Duel is canceled as the building begins to fall apart and Sayer is thrown down the center of the building, due to Carly and Sayer's Shadow Duel.
Misty finds Carly crying as she prepares to leave the building. Misty tells her that she has been chosen by the Earthbound Immortal, saying that her death and subsequent revival as a Dark Signer was already destined to occur, which proceeds to upset Carly even more to which she says that all of this is hard to take in all at once. Devack then arrives in a helicopter to pick up the two Dark Signers.
After Roman's Shadow Duel against Yusei concludes, Misty arrives along with the rest of her comrades, as the final battle between them and the Signers is about to unfold.
Misty waited for Akiza at the Original Enerdy Reactor's Lizard control unit, in an abandoned theme park. She is the last of the Dark Signers standing, when Akiza arrives. She guides Akiza into a hall of mirrors, where their Duel takes place.
During the Duel, Misty's geoglyph does not appear, and Akiza's birthmark doesn't react. Misty faces Akiza through the mirrors in the hall. Throughout the Duel, she explains what she believes to be the story of Toby's death, and subsequently her death as a resurrection, using her "Sad Story" cards to symbolize the events.
Akiza becomes tormented with the guilt and loses the will to continue the Duel. However, Sayer appears and saves Akiza from landing into a shard of shattered glass. He manipulates Akiza's mind and reawakens her Black Rose persona. Misty continues to inflict more damage to Akiza, who doesn't even flinch. The Black Rose Summons "Black Rose Dragon", shattering every mirror in the vicinity. With the mirrors gone, Misty confronts her opponent face-to-face.
Misty continues the duel against the Black Rose and Summons "Earthbound Immortal Ccarayhua". Yusei arrives and manages to trick Sayer into confessing that he was responsible for Toby's death. After Sayer tells her that Toby was weak and useless, Misty's heart is filled with anger, fueling Ccarayhua to approach Sayer, grab him with its tongue and devours him (in the English version Sayer is absorbed by Ccarayhua after snatching him with its tongue). With Sayer dead, this time for good, Misty states that she has finally avenged her brother.
Misty vanishes, at peace with Akiza.
Misty apologizes to Akiza and tries to surrender the duel. However Ccarayhua disallows it and takes control of her. Possessed, Misty proceeds to duel Akiza, who defends herself. Misty's spirit encourages Akiza to end the Duel and to protect the world as a Signer. Akiza proceeds to win the Duel, causing Misty to vanish. As she disappears, Misty leaves her locket, containing a picture of herself and Toby, and her final words are "Now, Akiza... protect this world, as a Signer! Please... remember us" (in the English version, Misty tells Akiza to tell Toby that she loves him if she ever finds him).