Oniisama e... (おにいさまへ…, Oniisama e...? lit. To [my respected] elder brother) is a Japanese manga series by Riyoko Ikeda. It has been adapted into an anime series that aired on NHK from July 1991 to May 1992.

It came to be known in English as Brother, Dear Brother due to the translation given to it by the fansub group TechnoGirls.

The series originally started out as a manga in the early-mid 1970s. The story is about a 16 year old girl Nanako Misonoo (御苑生奈々子, Misonoo Nanako?) who attends a prestigious academy and deals with life as a high school student via writing letters to her "brother". The manga has never been officially released in English, though it has been translated into Italian.

The anime series spans 39 episodes and ends when Nanako is seventeen. The show's themes are dark and controversial. Among them include suicide, abuse, incest, lesbianism, drug addiction, violence, divorce, and disease. The series was dubbed and released in Italy and France, though it was pulled after 7 episodes in France, due to strong adult content.

It was also released in Arabic speaking networks in the early 90s under the title "Akhy El Aziz" (My Dear Brother). It was shown a number of times before being taken off the air; the anime is rarely available to Arab audiences due to its content, as it is uncommon for an animated series with such content to be broadcast in an Arabic-speaking country, although the anime's content did receive some little editing. However unlike the French dub, all 39 episodes were broadcast.

Source: Wikipedia