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Pani Poni Dash!'s central storyline revolves around Rebecca Miyamoto, class 1-C's child prodigy homeroom teacher, and the antics of class 1-C. The characters attend a high school called the Peach Moon Academy (桃月学園, Momotsuki Gakuen?) where Rebecca has taken up a job as one of the teachers after being the youngest graduate at M.I.T. and is being watched by Aliens that are in space and screw up the story every now and then. Though the story never strays from the focus of the four first year classes labeled 1-A through 1-D, the mishaps that occur in them, the teacher's lounge, and on school trips also become sources of material for topical allusions regarding satire, anime, Internet, gaming, and popular culture.