Unlike her calm and rational brother, Virgil, Vanessa Walsh is much more high strung, angry and short-tempered. Vanessa is also the leader of a Vampire Terrorist Group who attempted to capture Pope Alessandro so that they could use his safety as a bargaining chip. Despite her anger, she was really hoping to free her people, rather than harm the Pope. Vanessa learned that there were some humans who cared about their hardships when Pope Alessandro XVIII stopped Brother Petros from taking her life. She would later destroy Dietrich's death hunters to save the Pope. She would also help the AX destroy Isaak's ship by explaining the mechanics of defensive shield surrounding the aircraft.