In a small country school, Sakura Mikan and Imai Hotaru are classmates and best friends - in their own way. Ditzy, emotional Mikan seems ill-matched with aloof, emotionless Hotaru, yet they are together all the time... until Hotaru gets called away to study at the strange and forbidding Alice Academy. In her anguish at being left behind, Mikan finally decides to follow her friend - and doing so, she makes a strange discovery.
Sakura Mikan, a girl from Northern of Japan, had a bestfriend named Imai Hotaru. Even though, she doesn't know it, but Hotaru was an alice. After 1-2 years of being friends, Hotaru went to another school where there were people like her, an alice. Mikan, so depressed about Hotaru leaving, went to the school and found at she was an alice as well. She found at that she had a cancellation alice which can cancel alices. Many students thought she somehow tricked the academy into thinking she was an alice. However, Mikan tries her hardest into proving their wrong, lifting up their hopes to be no. 1 and go see their families,etc. She does the best she can to make them friends and let them have confidence in themselves. And for some reason, she somehow changed the academy's students into becoming friends, and even, admirers. This anime is about friendship, love, selflessness, concern for others, and hope.