Prototype is a video game developed by Radical Entertainment and based on an original IP developed in-house. The game is intended for release in the summer of 2008 for the Playstation 3, Xbox 360 and PC platforms. The game is the first in a planned franchise.

The player controls the character of amnesiac Alex Mercer in New York City, with freedom similar to that of the Grand Theft Auto series and The Incredible Hulk: Ultimate Destruction, in which the player can visit most locations and interact with the environment while not engaged in missions. Alex will clash with the military's Black Watch Special Forces and the effects of a mutated viral epidemic as he works to discover the secrets of his past.

A key aspect of Prototype is the 'disguise or destroy' concept, which is tied to Alex's enemy-consuming and shapeshifting powers. Alex can consume the bodies of those he has killed, which gives him access to their memories, their experiences, and their physical forms. Alex can also shapeshift into more fantastic forms for attack, defense, or sensory enhancement. All of these together are intended to give players multiple ways to complete their objectives. Movement is simplified to allow more controls dedicated to shapeshifting, with Alex automatically navigating obstacles in a manner inspired by Parkour.