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Post Reply Random mutation
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Posted 10/25/17 , edited 10/25/17
If you mutate every cells in the body at random, do you still have the same human shape after a day? Or do you turn into a mush?
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Posted 10/25/17 , edited 10/25/17
You turn into dead meat.
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Posted 10/25/17 , edited 10/25/17
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Posted 10/25/17 , edited 10/25/17


Uh, this from Fate Stay Night ? But seriously, if this is the case we can turn into anything

P.S Yes I am trying to avoid these images when I Google the term


gornotck wrote:

You turn into dead meat.


No I become Cyclops
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Posted 10/25/17 , edited 10/25/17



Uh, this from Fate Stay Night ? But seriously, if this is the case we can turn into anything

P.S Yes I am trying to avoid these images when I Google the term


It seemed relevant. lol







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Posted 10/25/17 , edited 10/25/17

Ibkickin2 wrote:




Uh, this from Fate Stay Night ? But seriously, if this is the case we can turn into anything

P.S Yes I am trying to avoid these images when I Google the term


It seemed relevant. lol









Well there is a chance that all these random mutations hit the right key and I become a god :D

P.S These types of things never went well with anime , DNA^2
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Posted 10/25/17 , edited 10/25/17


You die and you become cancer.
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Posted 10/25/17 , edited 10/25/17
Random mutation is what my parents named me.
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Posted 10/25/17 , edited 10/25/17

bronzefoot wrote:

Random mutation is what my parents named me.


What an I say, if I say I want a bear's claw, I would go insert bear's DNA into my hand, turn on cell proliferation and have it grow into a bear's hand. Well the thing is DNA experiment is still on the infant stage. Well, I wouldn't suggest testing it on an organism, maybe on a tree, grow a bear's claw.

P.S And I am mixing DNA of two different species, I wouldn't know if cell signaling would work if someone did do a surgery(hate this term) and connected an animal part to human part would work out. Right there's the immune rejection problem

P.S As long as immune system and blood type has no rejection we could change identity among human, maybe swap the chromosomes

P.S So you can cultivate like cells from different people on your body
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Posted 10/25/17 , edited 10/25/17
Sounds like describing how cancer works..
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Posted 10/25/17 , edited 10/25/17

fredreload wrote:

If you mutate every cells in the body at random, do you still have the same human shape after a day? Or do you turn into a mush?



Well it depends. If you are born with a mutation, usually every cell in your body has that mutation, but it would be the same mutation in almost every cell.
If you are taking about taking every single cell and giving every single cell a random mutation (i.e. not necessarily the same) a number of things could happen:
-Most cells won't be different in any way because there are far more parts of the DNA that do not code for a gene
-Some cells will become cancerous because their cell death is disrupted
-Some cells might simply die
-Some cells might turn into a different kind of cell type

If you are taking about giving every cell more than one mutation (not only in your DNA but also mitochondria), then everything goes. You could start growing legs out of your eyes (happened in flies, correction: it was legs instead of antenna, but I do remember vaguely that there was something really creepy as well but can't remember what it was), get ears on your back (happened in rats) or theoretically become "younger" or maybe even immortal.
In theory if you mess around enough you could become a different species, say a unicorn

Maybe I should also add here that how you live changes which genes are active i.e. you can actively change the activity of your genes (turn some off, turn some which are usually off on and so on)
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Posted 10/25/17 , edited 10/25/17

Secret-of-Terra wrote:


fredreload wrote:

If you mutate every cells in the body at random, do you still have the same human shape after a day? Or do you turn into a mush?



Well it depends. If you are born with a mutation, usually every cell in your body has that mutation, but it would be the same mutation in almost every cell.
If you are taking about taking every single cell and giving every single cell a random mutation (i.e. not necessarily the same) a number of things could happen:
-Most cells won't be different in any way because there are far more parts of the DNA that do not code for a gene
-Some cells will become cancerous because their cell death is disrupted
-Some cells might simply die
-Some cells might turn into a different kind of cell type

If you are taking about giving every cell more than one mutation (not only in your DNA but also mitochondria), then everything goes. You could start growing legs out of your eyes (happened in flies), get ears on your back (happened in rats) or theoretically become "younger" or maybe even immortal.
In theory if you mess around enough you could become a different species, say a unicorn

Maybe I should also add here that how you live changes which genes are active i.e. you can actively change the activity of your genes (turn some off, turn some which are usually off on and so on)


Here's the idea, you can have cells from 100 different people pieced together, as long as it has no immune rejection and is of similar blood type. How do you deliver the DNA though, a virus, but even virus fails, I think, hmm. Do they ever? And even if virus do fail, like can't locate the right sequence, then you better count on nanomachines.
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Posted 10/25/17 , edited 10/25/17
I don't really get what you mean with 100 different people pieced together, but yes of course viruses fail in delivering what you want them to deliver. Sometimes viruses can get incorporated in your genome (instead of delivering what you want them to), if I recall my graduate courses correctly we are 5% virus anyway. Sometimes they simply are destroyed etc. You can use new methods like Crispr/cas if they ever become good enough to edit your genome and so on.

But what exactly do you want to achieve in the end? Or are you just asking for the heck of it
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Posted 10/25/17 , edited 10/25/17

Secret-of-Terra wrote:

I don't really get what you mean with 100 different people pieced together, but yes of course viruses fail in delivering what you want them to deliver. Sometimes viruses can get incorporated in your genome (instead of delivering what you want them to), if I recall my graduate courses correctly we are 5% virus anyway. Sometimes they simply are destroyed etc. You can use new methods like Crispr/cas if they ever become good enough to edit your genome and so on.

But what exactly do you want to achieve in the end? Or are you just asking for the heck of it


What am I trying to achieve D:, only Fred knows lol . I am thinking of in vivo DNA modification given how there are only a few studies conducted on it. What I mean by 100 people is that, you can have 100 different people's cells pieced together to form a hand, as long as they do not have immune rejection or blood type mismatch. This is important because if I intend to transform from a human to a bear, even if I do have the bear's DNA, it's protein structure would produce rejection with the rest of the body.

Right the problem is crispr and existing virus DNA changing method is that, they can go wrong and is not 100% accurate. Virus as I know, insert DNA at random places, and crispr can go off to different places. Maybe replace a whole chromosome? Haven't heard of that method.

So the idea is to see if a virus or crispr can change DNA in vivo at a correct spot 100% of the time. Which I think is unlikely =/. So the last step is to refer to nanomahine, which is still at its infancy
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Posted 10/25/17 , edited 10/25/17
Well, in-vivo dna modification is still at the very beginning. We barely have it down with simple organisms. In humans who probably have more cells than grains of sand in a desert, we are not even close to doing something like that.
Technically the bear dna won't cause a rejection but your body will, but yeah you are right, you need to produce proteins or other structures that our immune system will not try to kill.
Nothing is going to be 100%, trust me on this one. It doesn't matter if you have viruses, crispr, nanomachines or whatever, everything is going to make a mistake once in a while. Our own DNA repairing system or our own cells when dividing make mistakes, which can lead to problems such as cancer in very bad cases. Nothing is going to be 100%. What you maybe mean is something that detects mistakes and tries to repair them, but even those detection systems will make mistakes and "repair" something that doesn't need repair or oversee something that really needs repairing.

Replacing whole chromosomes seems very random. There are people who are born with too many or not enough chromosomes and usually they either have some kind of defect or don't even get born because they die before. Inserting a chromosome from another species (or a chromosome pair would be better) would probably lead to some crazy stuff and most probably end up killing you. I don't know if something like that has ever been done. What does occasionally happen in nature is that organisms duplicate their whole genome (happened in some worms).
If I ever hear about "chromosome transplantations" I will let you know

I have to say, I spent a lot of time studying about and working in genetic techniques but I didn't come up with such ideas
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