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Post Reply Random mutation
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23 / M / US
Posted 10/25/17 , edited 10/25/17
Not every cell uses every part of the genome
So for a decent portion of the cells, diddly squat would happen

It's the one's where something happens that are important
Random mutations of just one thing would probably result in little to no change.
The change could end up coding for the same thing
The change could end up coding for an equivalent thing
The change could end up coding for a thing that doesn't work and the cell dies

Only a minute (and likely irrelevant) fraction would be dangerous or interesting

And think about, cell's make mistakes all the time when copying themselves and it changes nothing.
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32 / M
Posted 10/25/17 , edited 10/26/17

Secret-of-Terra wrote:

Well, in-vivo dna modification is still at the very beginning. We barely have it down with simple organisms. In humans who probably have more cells than grains of sand in a desert, we are not even close to doing something like that.
Technically the bear dna won't cause a rejection but your body will, but yeah you are right, you need to produce proteins or other structures that our immune system will not try to kill.
Nothing is going to be 100%, trust me on this one. It doesn't matter if you have viruses, crispr, nanomachines or whatever, everything is going to make a mistake once in a while. Our own DNA repairing system or our own cells when dividing make mistakes, which can lead to problems such as cancer in very bad cases. Nothing is going to be 100%. What you maybe mean is something that detects mistakes and tries to repair them, but even those detection systems will make mistakes and "repair" something that doesn't need repair or oversee something that really needs repairing.

Replacing whole chromosomes seems very random. There are people who are born with too many or not enough chromosomes and usually they either have some kind of defect or don't even get born because they die before. Inserting a chromosome from another species (or a chromosome pair would be better) would probably lead to some crazy stuff and most probably end up killing you. I don't know if something like that has ever been done. What does occasionally happen in nature is that organisms duplicate their whole genome (happened in some worms).
If I ever hear about "chromosome transplantations" I will let you know

I have to say, I spent a lot of time studying about and working in genetic techniques but I didn't come up with such ideas

Hmm, if there is only an easy way of transferring chromosomes in and out of cell with a virus. One problem though. the genes on the chromosomes need to be activated at the correct spots. Meaning every chromosome, as much as they do look the same, are activated on different spots.
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27 / F
Posted 10/26/17 , edited 10/26/17
You underestimate the proofreading exonuclease ability of human DNA polymerase.
The vast majority of mutations are corrected immediately. However, the tiny percentage of mutation that gets through unchecked will accrue over the course of a lifetime.
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