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crispr reverse aging

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Posted 9/24/18 , edited 9/24/18
Guys, when we are young as a child our organs are smaller and then as we hit puberty, our organs become bigger. What causes this change? The release of growth hormone from the glands designed in our DNA. And then puberty stops and we age again from 18 to 19 and so on. Again, aging is designed in the DNA. If we could use crispr to swap out the strands of DNA that result in aging, we can stop our current age.

It is designed to upshift or downshift the epigenome based on a hormone that ages you from 29 day 1 to 29 day 2. But is this hormone important? Well, you are not that much different from 29 day 1 to 29 day 2, so why age? Just stop all shifts
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Posted 9/24/18 , edited 9/24/18

fredreload wrote:so why age?


cuz the aliens who are responsible for the missing link designed it thusly
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Posted 9/24/18 , edited 9/24/18

BushyBrowSensei wrote:


fredreload wrote:so why age?


cuz the aliens who are responsible for the missing link designed it thusly


Ya, what a jerk lol . But seriously if we could just swap out the DNA responsible for the shifts and modify like 90% of the DNA in the body
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Posted 9/24/18 , edited 9/24/18

Humms 
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Posted 9/25/18 , edited 9/25/18

fredreload wrote:

Guys, when we are young as a child our organs are smaller and then as we hit puberty, our organs become bigger. What causes this change? The release of growth hormone from the glands designed in our DNA. And then puberty stops and we age again from 18 to 19 and so on. Again, aging is designed in the DNA. If we could use crispr to swap out the strands of DNA that result in aging, we can stop our current age.

It is designed to upshift or downshift the epigenome based on a hormone that ages you from 29 day 1 to 29 day 2. But is this hormone important? Well, you are not that much different from 29 day 1 to 29 day 2, so why age? Just stop all shifts


Hmm.

There have been cases of rapid aging, where one individual would look to be like a child, but wouldn't live past the age of 13 or 14, because of a disease.

Other cases where the individual would look like a child /teenager because of a growth hormone deficiency, and age would seem timeless as they never change past a certain point, keeping a youthful appearance, but still aging normally with other underlying issues.

So to stop the aging process completely.... are our bodies capable enough to handle it?

Organs without a doubt, they don't last forever, both in the original body, or donated, but I actually think if we support one of the best life cycles so that those organs are given the best possible health and function, and still kept in the original body of said user, how long can we actually use our original organs if we were to defy the aging process? Do our organs age as we do?


Cut out the middle man Fred. We must genetically modify/enhance human organs in order to meet expectations. If we can truly stop the aging process, there must be a greater purpose for that body. Could a human live past the age of 130 And still function like a 20 or 30 year old? Could we actually offer people the chance at an endless life ?

Fred, I implore you to seek out willing subjects to test such a theory, the future depends on your success. The human body in its current state is fragile, but the human mind can offer years of potential. Our thoughts are in the wrong place to create AI to care for us, we must become one with technology.
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runec 
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Posted 9/25/18 , edited 9/26/18

fredreload wrote:
so why age?


Putting aside the whole "that's not how any of this works problem" the "so why age" is because of evolution. We evolve because we keep issuing new models so to speak. If we cease aging ( and thus dying ) we effectively become a genetic bottleneck on our own evolution. Which would likely lead us to having to use genetic engineering to create new kinds of humans to adapt to changing environmental factors.

Look at it this way: Say you became immortal 500 years ago. You would be shorter, smaller, less intelligence and less healthy than a modern human. You'd be immortal, sure, but obsolete and since we're only talking about ceasing the aging process you could still be killed by the plethora of health risk factors you would have as someone born 500 years ago. Nevermind how poorly adapted you would be to the modern world. WE'RE not even well adapted to the modern world as is.

Being an immortal member of a species as rapidly changing as humans would suck. You'd become the genetic equivalent of a Nokia 3310.
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Posted 9/25/18 , edited 9/26/18

runec wrote:


fredreload wrote:
so why age?


Putting aside the whole "that's not how any of this works problem" the "so why age" is because of evolution. We evolve because we keep issuing new models so to speak. If we cease aging ( and thus dying ) we effectively become a genetic bottleneck on our own evolution. Which would likely lead us to having to use genetic engineering to create new kinds of humans to adapt to changing environmental factors.

Look at it this way: Say you became immortal 500 years ago. You would be shorter, smaller, less intelligence and less healthy than a modern human. You'd be immortal, sure, but obsolete and since we're only talking about ceasing the aging process you could still be killed by the plethora of health risk factors you would have as someone born 500 years ago. Nevermind how poorly adapted you would be to the modern world. WE'RE not even well adapted to the modern world as is.

Being an immortal member of a species as rapidly changing as humans would suck. You'd become the genetic equivalent of a Nokia 3310.


But you have to admit. If we decide to be immortal and not age in 2020, how much do you really think the human body and mind can evolve?

All we can do is become the most intelligent person on the planet with endless time for knowledge. We just need a top performing candidate.
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Posted 9/25/18 , edited 9/26/18

runec wrote:


fredreload wrote:
so why age?


Putting aside the whole "that's not how any of this works problem" the "so why age" is because of evolution. We evolve because we keep issuing new models so to speak. If we cease aging ( and thus dying ) we effectively become a genetic bottleneck on our own evolution. Which would likely lead us to having to use genetic engineering to create new kinds of humans to adapt to changing environmental factors.

Look at it this way: Say you became immortal 500 years ago. You would be shorter, smaller, less intelligence and less healthy than a modern human. You'd be immortal, sure, but obsolete and since we're only talking about ceasing the aging process you could still be killed by the plethora of health risk factors you would have as someone born 500 years ago. Nevermind how poorly adapted you would be to the modern world. WE'RE not even well adapted to the modern world as is.

Being an immortal member of a species as rapidly changing as humans would suck. You'd become the genetic equivalent of a Nokia 3310.



1. Look at it this way: Say you became immortal 500 years ago. You would be shorter, smaller, less intelligence and less healthy than a modern human. true


2. You'd be immortal, sure, but obsolete and since we're only talking about ceasing the aging process you could still be killed by the plethora of health risk factors you would have as someone born 500 years ago.

true but the health risks are lowered if you cure aging.

3. Being an immortal member of a species as rapidly changing as humans would suck. You'd become the genetic equivalent of a Nokia 3310. True in the past in the future not so much as it's more likely we will be forgoing regular evolution for genetically manufactured evolution and if we can do it in living people who are ageless it becomes a non-issue.

4. If we cease aging ( and thus dying ) we effectively become a genetic bottleneck on our own evolution. Which would likely lead us to having to use genetic engineering to create new kinds of humans to adapt to changing environmental factors.

True and good thats what is likely to happen hopefully instead of new kinds of humans it's for those preexisting.
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runec 
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Posted 9/25/18 , edited 9/25/18

Humms wrote:
But you have to admit. If we decide to be immortal and not age in 2020, how much do you really think the human body and mind can evolve?


As long as environmental factors and selection pressures exist we'll keep changing. Unless the world, technology and culture all become frozen and static in time we're never not going to keep evolving in some direction or another. While it's true you aren't going to see us suddenly sprout gills or anything we are still evolving. On a genetic level our evolution actually accelerated once we started farming and staying in one place.

I mean, think about it for a moment: The world has changed so rapidly that physically humanity cannot keep up. We haven't adapted to our own creation yet. We work and sleep hours we were never suppose to, eat crap we weren't build to consume and handle increasingly complex technology at increasingly younger ages thus wiring our brains different with each generation. On top of that, human mobility has never been so high in all of human history. 200 years ago if you were in the States you probably weren't going to be making babies on the regular with anyone from Australia or India. Now though human mobility has opened up previously isolated gene pools and nature favours dissimilar genetic combinations.

Mother Nature wants you to stick it in the weirdest hole you can find >.>

Another self inflicted risk will be if any kind of gene editing / immortality technology does emerge and is not widely available. We could cause ourselves to diverge into two separate species. Detroit will become ( may already be ) the capital of the Morlock empire.




Humms wrote:
All we can do is become the most intelligent person on the planet with endless time for knowledge. We just need a top performing candidate.


It would be easier to just have a computer do that. Which it will long before we christen the immortal genius among us.




Ryulightorb wrote:
true but the health risks are lowered if you cure aging.


Some are, sure but just turning off aging wouldn't roll back damage from lifestyle habits, epigenetics, childhood exposures, poor childhood nutrition, etc etc.



Ryulightorb wrote:
True and good thats what is likely to happen hopefully instead of new kinds of humans it's for those preexisting.


We'll probably see designer babies before anything else unfortunately. There's people rich enough to buy it and people unscrupulous enough to sell it. While rich Americans would just go on pregnancy vacations in countries with no genetic editing laws. At which point we're in a dangerous grey area of artificial natural selection.
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Posted 9/25/18 , edited 9/25/18

runec wrote:


Humms wrote:
But you have to admit. If we decide to be immortal and not age in 2020, how much do you really think the human body and mind can evolve?


As long as environmental factors and selection pressures exist we'll keep changing. Unless the world, technology and culture all become frozen and static in time we're never not going to keep evolving in some direction or another. While it's true you aren't going to see us suddenly sprout gills or anything we are still evolving. On a genetic level our evolution actually accelerated once we started farming and staying in one place.

I mean, think about it for a moment: The world has changed so rapidly that physically humanity cannot keep up. We haven't adapted to our own creation yet. We work and sleep hours we were never suppose to, eat crap we weren't build to consume and handle increasingly complex technology at increasingly younger ages thus wiring our brains different with each generation. On top of that, human mobility has never been so high in all of human history. 200 years ago if you were in the States you probably weren't going to be making babies on the regular with anyone from Australia or India. Now though human mobility has opened up previously isolated gene pools and nature favours dissimilar genetic combinations.

Mother Nature wants you to stick it in the weirdest hole you can find >.>

Another self inflicted risk will be if any kind of gene editing / immortality technology does emerge and is not widely available. We could cause ourselves to diverge into two separate species. Detroit will become ( may already be ) the capital of the Morlock empire.


agreed, although humans were meant to withstand many environmental challenges, whether it be extreme heat or cold, the change in atmospheric pressure, I believe we can train our bodies through technological means. An example would be training for low and high altitude situations, again, this is because of our advancements in technology, not so much improving our genetics and evolving, there are constants and limits the human body can physically take, but there are also limits that can be pushed, though we will always reach a breaking point because of our physical limitations and structure. We can simulate many environmental situations in a confined space. It is the methods we are presented. We create a faster way to teach and train humans, and I believe that everyone has the chance to correct themselves if given this immortal opportunity.

Yes, younger minds will be better to shape and mold, and it is an easier method, but I find the way we go about death has become so primitive, why not salvage what we have in order to better our chances at creating a more refined individual that has been so misguided by the restrictions of a not so equal opportunity and quality of life, instead of searching for hundreds of years for the right way of going about creating the perfect person. I just see this more as a learning experience for those who hold themselves back, and possibly holding back the next line of children they have. We can manipulate the human mind, so why not do so for the good of all.

True, it is all about mixing genetics, which is why it would be a good idea to Spread the seed until we have found the perfect bloodline and mixture of race.......... and then we make them immortal

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Posted 9/25/18 , edited 9/26/18
Aging is a part of life. Better to accept it than to fear and resist it.
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Posted 9/25/18 , edited 9/25/18

Humms wrote:


runec wrote:


Humms wrote:
But you have to admit. If we decide to be immortal and not age in 2020, how much do you really think the human body and mind can evolve?


As long as environmental factors and selection pressures exist we'll keep changing. Unless the world, technology and culture all become frozen and static in time we're never not going to keep evolving in some direction or another. While it's true you aren't going to see us suddenly sprout gills or anything we are still evolving. On a genetic level our evolution actually accelerated once we started farming and staying in one place.

I mean, think about it for a moment: The world has changed so rapidly that physically humanity cannot keep up. We haven't adapted to our own creation yet. We work and sleep hours we were never suppose to, eat crap we weren't build to consume and handle increasingly complex technology at increasingly younger ages thus wiring our brains different with each generation. On top of that, human mobility has never been so high in all of human history. 200 years ago if you were in the States you probably weren't going to be making babies on the regular with anyone from Australia or India. Now though human mobility has opened up previously isolated gene pools and nature favours dissimilar genetic combinations.

Mother Nature wants you to stick it in the weirdest hole you can find >.>

Another self inflicted risk will be if any kind of gene editing / immortality technology does emerge and is not widely available. We could cause ourselves to diverge into two separate species. Detroit will become ( may already be ) the capital of the Morlock empire.


agreed, although humans were meant to withstand many environmental challenges, whether it be extreme heat or cold, the change in atmospheric pressure, I believe we can train our bodies through technological means. An example would be training for low and high altitude situations, again, this is because of our advancements in technology, not so much improving our genetics and evolving, there are constants and limits the human body can physically take, but there are also limits that can be pushed, though we will always reach a breaking point because of our physical limitations and structure. We can simulate many environmental situations in a confined space. It is the methods we are presented. We create a faster way to teach and train humans, and I believe that everyone has the chance to correct themselves if given this immortal opportunity.

Yes, younger minds will be better to shape and mold, and it is an easier method, but I find the way we go about death has become so primitive, why not salvage what we have in order to better our chances at creating a more refined individual that has been so misguided by the restrictions of a not so equal opportunity and quality of life, instead of searching for hundreds of years for the right way of going about creating the perfect person. I just see this more as a learning experience for those who hold themselves back, and possibly holding back the next line of children they have. We can manipulate the human mind, so why not do so for the good of all.

True, it is all about mixing genetics, which is why it would be a good idea to Spread the seed until we have found the perfect bloodline and mixture of race.......... and then we make them immortal



Thanks for the many replies . I am actually on to the technicalities of epigenome. As attributing the epigenetic shift as the primary reason for aging.

Some people call DNA damage as the primary source of aging. Believe me I was stuck on this concept for many years.

But then I found IPSC(induced pluripotent stem cell) which essentially revert any type of aged differentitated cell(skin, liver, neuron) into a stem cell.

And guess what the DNA damage of this reverted stem cell has? 0. It's got restored telomere length, restored DNA damage, and restored mitochondrial damage.

This got me thinking that the epigenetics is quite credible and if the mark in the cell stays the same from 29 day 1 to 29 day 2 then most likely you could stop aging.

But any drug that mess with DNA methylation have quite a serious side effect. And this is a research post, I am not recommending any drug nor do I want you to take it. I do know a drug that stops all DNA methylation(a hypomethylating agent) but it's not like you just stop all DNA methylation to stop aging, maybe stops all DNA methylation and DNA demethylation, I dunno if I'll survive?

So I want you to tell me what your idea of aging is and how to prevent it. DNA damage? Epigenetic drift? You name it

P.S OSKM is one method


Ruleaus wrote:

Aging is a part of life. Better to accept it than to fear and resist it.


We are at an age where we could overcome aging , at least I hope
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Posted 9/25/18 , edited 9/25/18
Yes, maybe we are able, but I don’t want it if it’s going to require me giving up my being human. For example, transhumanists talk about merging with machine to extend our life span. I don’t know about you, but I don’t want to become a cyborg.

You get one body. Take care of it the best you can now to slow the aging process by natural means. Don’t, however, become so desperate to avoid the inevitable so as to give up who you are.
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Posted 9/26/18 , edited 9/26/18

Ruleaus wrote:

Yes, maybe we are able, but I don’t want it if it’s going to require me giving up my being human. For example, transhumanists talk about merging with machine to extend our life span. I don’t know about you, but I don’t want to become a cyborg.

You get one body. Take care of it the best you can now to slow the aging process by natural means. Don’t, however, become so desperate to avoid the inevitable so as to give up who you are.


Well, if there's one thing I'm counting on, it's metamorphosis. Don't get me wrong it is an elegant process. When a caterpillar becomes a butterfly it needs it's head(neurons) where it needs to be for a successful transformation. And that also applies for human. And a smooth transistion. For instance if I want to become a 5 year old self, I need to make sure my brain is where my brain needs to be and induce transdifferentiation on the rest of the body and then create a neck where it needs to be.

That, as the same as a caterpillar becomes a butterfly, is all done in the same strand of DNA except with a different set of gene expression, meaning we need to manually program the transistion of becoming a 5 year old and attach that as an instruction into our current DNA using crispr. So we need to modify every single strand of DNA in the body with attachment preferably using crispr. That is the conclusion I came to, since there is no other way of inducing a transdifferentiation. This probably won't be done until some pretty advanced biological institute in the next 100 years, even 50 years since too fast for this to complete.

Ya, I also don't like the cyborg idea, it needs to be elegant and hopefully painless.

P.S. And so if anyone ever feels like metamorphing an animal. And then a definite human trial through an unconscious body.
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Posted 9/26/18 , edited 9/26/18

Humms wrote:
agreed, although humans were meant to withstand many environmental challenges, whether it be extreme heat or cold, the change in atmospheric pressure, I believe we can train our bodies through technological means. An example would be training for low and high altitude situations, again, this is because of our advancements in technology, not so much improving our genetics and evolving, there are constants and limits the human body can physically take, but there are also limits that can be pushed, though we will always reach a breaking point because of our physical limitations and structure. We can simulate many environmental situations in a confined space. It is the methods we are presented. We create a faster way to teach and train humans, and I believe that everyone has the chance to correct themselves if given this immortal opportunity.


We are, overall, a very adaptable species but yes we naturally specialize to our current environment. If you drop a bunch of Norwegians and a bunch of Ethiopians in the Sahara desert one of them's going to have a markedly lower survival rate. If the environmental shifts are too rapid adaption can't keep up. We are masters of technologically adapting to differing environments but if anything should occur that affect said technology ( the end of fossil fuels resources before we've committed to alternative energy for example) we could be fubar for a while.

Let's face it, as a species we aren't great at long term planning and half of us generally like to refuse anything will ever change to begin with.

Training adaptions isn't going to be as widely effective as generational ones. Yes, you can acclimatize to say a higher altitude in a few weeks but you're not going to have the increased lung capacity, improved blood circulation and other physiological advantages of Tibetans for instance that have developed it over generations of natural selection. You've only acclimatized, not actually adapted, and you'll lose it soon as you leave that environment.




Humms wrote:Yes, younger minds will be better to shape and mold, and it is an easier method, but I find the way we go about death has become so primitive, why not salvage what we have in order to better our chances at creating a more refined individual that has been so misguided by the restrictions of a not so equal opportunity and quality of life, instead of searching for hundreds of years for the right way of going about creating the perfect person. I just see this more as a learning experience for those who hold themselves back, and possibly holding back the next line of children they have. We can manipulate the human mind, so why not do so for the good of all.


Well, because once again we're idiots and are bad at long term planning. We're also unwilling to offer assistance to those suffering generational deficiencies due to environment ( general poverty for example has very real and very significant life long health effects ). With what we know now about things like epigenetics were your grandparents lifestyle can literally affect your physiology we *should* be looking long and hard at finding an optimal path for childhood development / environment. Then actually working to ensure everyone has access to it. But, as the Americans so oft remind us, that's SOCIALIZM and Hitler will come back from the dead if we dare offer a helping hand to those less fortunate to ourselves. >.>


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