messenger RNA is immortality
6103 cr points
Send Message: Send PM GB Post
32 / M
Offline
Posted 7/28/17 , edited 7/28/17
The same thing I posted in another forum:

New plan, a hack using messenger RNA capable of transforming the cell back to its previous state. Why modify transcription factors and genes when the end result is a messenger RNA? Just target the cell's ribosome and send the artificial messenger RNA over. One problem, delivery. Deliver the correct messenger RNA into every single cell is not a currently known technology. Transfection with virus is possible but even then it is not guaranteed 100% for the cell to transform.

First, check the messenger RNA that IPSC produce. Next, spreads that messenger RNA to all the cells in the entire body to reproduce the SALK experiment. Then we tune the messenger RNA from there

How many rats do we need for this experiment? Check the video below
https://www.youtube.com/watch?v=dAxZVZgpmI0
17085 cr points
Send Message: Send PM GB Post
Offline
Posted 7/28/17 , edited 7/28/17
Don't kill the messenger?
Posted 7/28/17 , edited 7/28/17
It's a good thing I did biology at school otherwise I would have the slightest clue what you were talking about.
20208 cr points
Send Message: Send PM GB Post
27 / M
Offline
Posted 7/28/17 , edited 7/28/17
I wonder what the world was like pre-RNA days.

And what catalyzed the formation of ribonucleotide precursors from simpler molecules?

6103 cr points
Send Message: Send PM GB Post
32 / M
Offline
Posted 7/28/17 , edited 7/28/17

riverjustice wrote:

I wonder what the world was like pre-RNA days.

And what catalyzed the formation of ribonucleotide precursors from simpler molecules?



Not sure, I got the idea from transcription factors. Transcription factor is a protein that would allow binding to a segment of DNA in the nucleus that is otherwise off. By enable 4 transcription factors, known as the Yamanaka factors, the cell would slowly change from a somatic cell to a stem cell.

Now you could hack in the transcription factors into the cell, there are 2600 of them. And what the transcription factors do is that they help transcribe a messenger RNA. So to get a more accurate result, without playing with 2600 transcription factors is just to hack in a customized messenger RNA. Keep in mind this messenger RNA would be similar to the one derived from the Yamanaka factors.

What you are referring to is probably translation.

Here is a video on transcription and translation.
https://www.youtube.com/watch?v=2BwWavExcFI
20208 cr points
Send Message: Send PM GB Post
27 / M
Offline
Posted 7/28/17 , edited 7/28/17

fredreload wrote:


riverjustice wrote:

I wonder what the world was like pre-RNA days.

And what catalyzed the formation of ribonucleotide precursors from simpler molecules?



Not sure, I got the idea from transcription factors. Transcription factor is a protein that would allow binding to a segment of DNA in the nucleus that is otherwise off. By enable 4 transcription factors, known as the Yamanaka factors, the cell would slowly change from a somatic cell to a stem cell.

Now you could hack in the transcription factors into the cell, there are 2600 of them. And what the transcription factors do is that they help transcribe a messenger RNA. So to get a more accurate result, without playing with 2600 transcription factors is just to hack in a customized messenger RNA. Keep in mind this messenger RNA would be similar to the one derived from the Yamanaka factors.

What you are referring to is probably translation.

Here is a video on transcription and translation.
https://www.youtube.com/watch?v=2BwWavExcFI


I'm referring to how RNA was probably the key to the beginning of life. And how simple molecules were responsible for creating RNA. But the biggest mystery is the catalyst that first created RNA.
6103 cr points
Send Message: Send PM GB Post
32 / M
Offline
Posted 7/28/17 , edited 7/28/17

HateKillingCamels wrote:

It's a good thing I did biology at school otherwise I would have the slightest clue what you were talking about.


You actually know what I am saying ? That you could reset the entire cell back to the previous state with a correct messenger RNA?


riverjustice wrote:


fredreload wrote:


riverjustice wrote:

I wonder what the world was like pre-RNA days.

And what catalyzed the formation of ribonucleotide precursors from simpler molecules?



Not sure, I got the idea from transcription factors. Transcription factor is a protein that would allow binding to a segment of DNA in the nucleus that is otherwise off. By enable 4 transcription factors, known as the Yamanaka factors, the cell would slowly change from a somatic cell to a stem cell.

Now you could hack in the transcription factors into the cell, there are 2600 of them. And what the transcription factors do is that they help transcribe a messenger RNA. So to get a more accurate result, without playing with 2600 transcription factors is just to hack in a customized messenger RNA. Keep in mind this messenger RNA would be similar to the one derived from the Yamanaka factors.

What you are referring to is probably translation.

Here is a video on transcription and translation.
https://www.youtube.com/watch?v=2BwWavExcFI


I'm referring to how RNA was probably the key to the beginning of life. And how simple molecules were responsible for creating RNA. But the biggest mystery is the catalyst that first created RNA.


Some refers the origin of life to be asteroids carrying viruses crashing on to earth, high school physics lol, though how credible this is is to be debated
Posted 7/28/17 , edited 7/28/17

fredreload wrote:


HateKillingCamels wrote:

It's a good thing I did biology at school otherwise I would have the slightest clue what you were talking about.


You actually know what I am saying ? That you could reset the entire cell back to the previous state with a correct messenger RNA?


Nope, I just know what rna is so I can gather it's about biology. Other than that I don't have a clue.
6103 cr points
Send Message: Send PM GB Post
32 / M
Offline
Posted 7/28/17 , edited 7/28/17

HateKillingCamels wrote:


fredreload wrote:


HateKillingCamels wrote:

It's a good thing I did biology at school otherwise I would have the slightest clue what you were talking about.


You actually know what I am saying ? That you could reset the entire cell back to the previous state with a correct messenger RNA?


Nope, I just know what rna is so I can gather it's about biology. Other than that I don't have a clue.


It involves a bit of partial reprogramming. The idea is to use one messenger RNA for the entire body, well that is the easy part, if you need a different messenger RNA for each cell you'll need the Kobayashi Dragon method. But from how IPSC works it seems you can have a universal messenger RNA for all cells. Would that mess up my sperm cells, I have no idea, I hope it does not turn me into some kind of monster


P.S How can you tell the effect of a particular strand of RNA? Well, be prepared to have lots and lots of lab rats
P.S If you aren't thrilled by scicence then sorry, Fred is probably being an ass
You must be logged in to post.