John Blades Clarke (April 14, 1833 – May 23, 1911) was a U.S. Representative from Kentucky.
Born near Augusta, Kentucky, Clarke attended the common schools and Augusta (Kentucky) College. He taught school in the winters of 1851 and 1852. He studied law in Augusta, Kentucky. He was admitted to the bar on April 20, 1854, and commenced practice in Rockport, Indiana, in January 1885. He moved to Brooksville, Kentucky, in December 1855 and continued the practice of law. He served as prosecuting attorney of Bracken County 1858-1862. He served as member of the State senate 1867-1870.
Clarke was elected as a Democrat to the Forty-fourth and Forty-fifth Congresses (March 4, 1875-March 3, 1879). He declined to be a candidate for renomination in 1878. He resumed the practice of his profession. He died in Brooksville, Kentucky, May 23, 1911. He was interred in Mount Zion Cemetery, near Brooksville, Kentucky.