When two doors are discovered in an ancient ruin, the gateways to shinkai, the realm of the shinzoku (Gods) and makai, the realm of the mazoku (Demons) are irreversably opened. The races of human, shinzoku, and mazoku come together in the mortal world and nothing will ever be the same. One day, two new families move next door to a boy who had previously been living a very peaceful life. In one house lived the family of the King of the Gods, and in the other lived the family of the King of the Demons. Both families had one daughter whose single wish to live next to the boy they had fallen in love with years ago has just been fulfilled. Also living with the boy is his childhood friend. With these three girls vying for his affections, the boy finds that his new life filled with despair, jealousy, and just a little hope is beginning.
Written by and illustrated by Shiroi Kusaka, a manga adaptation of Shuffle! titled "Shuffle! Days in the Bloom" was first serialized monthly in Comptiq in December 2003, a month before the release of the visual novel, until its conclusion in December 2006.The twenty-six chapters were then compiled by Kadokawa Shoten into six tankōbon volumes, which were later released from August 8, 2004 to January 10, 2007. A second manga series, a comic anthology titled Shuffle! Comic à la Carte written by Comptiq's Editorial Department, was published across five tankōbon volumes by Kadokawa Shoten between July 8, 2004 and December 10, 2005.
Naoto Hosoda directed an anime adaptation of Shuffle! that was produced by Asread. A special prologue DVD was released on May 27, 2005. It was broadcasted in Japan on WOWOW and aired between July 7, 2005 and January 5, 2006 spanning twenty-four episodes. The anime combines elements from all of the characters' paths from the game into one plot, although it differs from the game by adding some elements, such as the idol clubs formed around Sia, Nerine, and Kaede, and removing others, such as the H-scenes. The anime's opening theme is "You" by Yuria, and the ending theme is "Innocence" by Miyuki Hashimoto. The series was released across twelve Region 2 DVD compilation volumes in Japan.